![]() Recently, salvinorin A has been researched for its potential beneficial effects for a variety of central nervous system illnesses, but reports suggest that its this ingredient that makes the salvia experience so unique, and usually uncomfortable or even terrifying. The active ingredient in salvia is called salvinorin A - a dopamine-reducing kappa-opioid receptor that’s responsible for the hallucinogenic effect of the salvia plant. So are there any health benefits to ingesting or smoking salvia leaves, or is it just another dangerous drug that should be banned in the U.S.? Studies do suggest that the sage species can be considered for drug development because of their therapeutic and pharmacology activities in many countries of Asia and the Middle East, especially China and India, but there’s varying opinions about whether or not the risks outweigh the benefits when it comes to using salvia divinorum. For centuries, salvia has been used in religious rituals in South America for its psycho-mimetic effects, but today it’s often used by young adults who are looking to experience a short-term trip. Street names for salvia include Magic Mint, Sally D, Diviners Sage, Seer’s Sage, Shepherdess’s Herb and Purple Sticky™, which is a popular brand name that’s sold in smoke shops. Salvia is a naturally occurring hallucinogenic plant that belongs to the sage family. Although the herb’s use as a recreational and medicinal drug is becoming more popular, the scientific literature documenting the benefits and negative consequences of salvia is scarce. ![]() The long-term impact of using salvia is still unclear, and there are concerns that it may effect your mental health. And reports by the National Institute on Drug Abuse for Teens indicate that 1.5 percent of 12th graders have recently used salvia. Researchers found that 4.4 percent of just over 1,500 students reported using salvia at least once within the past 12 months. and invited to participate in an online survey. For the study, a sample of college students were randomly drawn from a large public university in the southwestern U.S. Research published in Drug and Alcohol Dependence in 2008 indicates that salvia is becoming a significant member of the list of drugs that are used by college students. In recent years, especially after a video of teen pop star Miley Cyrus using the drug surfaced in 2010, the rising popularity of recreational salvia in the U.S. Historically, salvia was used by the Mazatecs for divination and shamanism, and it’s been suggested that the herb’s use may even date back to the Aztecs. Although adolescents and college students are just beginning to experiment with this powerful herb, it’s no newbie to the list of psychedelics. 10.1016/j.jemermed.2009.05.Salvia divinorum has become increasingly popular as a recreational drug for its hallucinogenic effects. Salvia divinorum: exposures reported to a statewide poison control system over 10 years. dea.gov/pr/multimedia-library/publications/drug_of_abuse.pdf#page=85 related-topics/trends-statistics/infographics/monitoring-future-2015-survey-results ![]() Monitoring the future 2015 survey results.general/newsletter/erowid_newsletter6.pdf Learning and memory impairment induced by salvinorin A, the principal ingredient of salvia divinorum, in wistar rats. You can learn more about how we ensure our content is accurate and current by reading our editorial policy. Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. In severe cases, you may experience paranoia and possibly a panic attack. Worries about the effects of the drug and fear of a “bad trip” may occur with salvia use. This study was conducted in rats, so it’s unclear how this translates to humans. One study found that salvia use may have negative effects on learning and impair long-term memories. Effects on learning and long-term memory.One study found that people who use salvia, either alone or with alcohol or other drugs, were more likely to experience neurologic, cardiovascular, and gastrointestinal side effects. Salvia isn’t considered addictive - you’re unlikely to develop a chemical dependency on the drug - but many people who use it become accustomed to using the drug for the “high” effects. However, the possible issues are serious and worth consideration. Because research is limited, the list of possible side effects and risks is short. Salvia is often marketed as a “legal high” or a “natural high,” but that doesn’t mean you shouldn’t take precautions if you use it. Salvia studies are few and far between, but researchers are looking to better understand how the drug works and what effects it may have on the body and brain.
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